Iranian Supreme Leader Ayatollah Ali Khamenei said on Saturday:

"We have repeatedly said we don't negotiate with the U.S. on regional or international affairs; not even on bilateral issues. There are some exceptions like the nuclear program that we negotiated with the Americans to serve our interests."

U.S. policies in the region were "180 degrees" opposed to Iran's, he said in a speech at a Tehran mosque punctuated by chants of "Death to America" and "Death to Israel".

"We will never stop supporting our friends in the region and the people of Palestine, Yemen, Syria, Iraq, Bahrain and Lebanon. Even after this deal our policy towards the arrogant U.S. will not change," he said.

http://www.reuters.com/article/2015/07/18/us-iran-nuclear-khamenei-idUSKCN0PS05320150718

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Nuclear deal will not change Iran's relations with U.S.: supreme leader